Luis Sera is a native of the Spanish village featured in Resident Evil 4. After returning from Madrid, where he pursued a career in the police force, Luis was hired by Osmund Saddler as a researcher for the Las Plagas parasite, experimenting with it to enhance the abilities of the host it infected. After some time, Luis became dissappointed of Saddler’s intentions, and he betrayed Saddler by stealing a Plaga sample. Saddler discovered him, and ordered for him to be tied up inside a closet, waiting for his fate. Leon S. Kennedy finds Sera and frees him, making Luis his ally. Luis helps Leon find Ashley Graham, and assists them in escaping Spain, as well as avoiding the Plaga parasite to grow inside Leon.